Publications
2021
Miller, HW, Tam, TSY, and Ralston, KS. Entamoeba histolytica develops resistance to complement deposition and lysis after acquisition of human complement regulatory proteins through trogocytosis. mBio. In press.
Bettadapur, A, Hunter, SS*, Suleiman, RL*, Ruyechan, MC, Huang, W, Barbieri, CG, Miller, HW, Tam, TSY, Settles, ML, and Ralston, KS. Establishment of quantitative RNAi-based forward genetics in Entamoeba histolytica and identification of genes required for growth. PLOS Pathogens. In press.
Suleiman, RL, and Ralston, KS. Growth and genetic manipulation of Entamoeba histolytica. Current Protocols. In press.
2020
Bettadapur, A, and Ralston, KS. 2020. Direct and high-throughput assays for human cell killing through trogocytosis by Entamoeba histolytica. Molecular and Biochemical Parasitology. 239:111301.
Bettadapur, A*, Miller, HW*, and Ralston, KS. 2020. Biting off what can be chewed: Trogocytosis in health, infection and disease. Infection and Immunity. 88:e00930-19. Journal Cover. *equal authorship. Part of the Collection: Early-Career Scientists Shaping the New Microbiology. Infection and Immunity. 88:e00129-20.
Gilmartin, AA, Ralston, KS, and Petri, WA, Jr. 2020. Inhibition of Amebic Cysteine Proteases Blocks Amebic Trogocytosis but not Phagocytosis. J Infect Dis. 221(10):1734-1739.
2019
Miller, HW, Suleiman, RL, and Ralston, KS. 2019. Trogocytosis by Entamoeba histolytica mediates acquisition and display of human cell membrane proteins and evasion of lysis by human serum. mBio. 10(2):e00068-19.
2017
Gilmartin, AA, Ralston KS, and Petri, WA, Jr. 2017. Inhibition of amebic lysosomal acidification blocks amebic trogocytosis and cell killing. mBio. 8(4):e01187-17.
2016
2016. Katherine Ralston: Attitude, Resilience and Cell-Nibbling Parasites. Trends in Parasitology. 32(12):913-914.
2015
Ralston, KS. 2015. Taking a bite: Amoebic trogocytosis in Entamoeba histolytica and beyond. Current Opinion in Microbiology. 28:26-35.
Ralston, KS. 2015. Chew on this: Amoebic trogocytosis and host cell killing by Entamoeba histolytica. Trends in Parasitology. (9):442.
2014
Ralston, KS, Solga, MD, Mackey-Lawrence, NM, Somlata, Bhattacharya, A, and Petri, WA, Jr. 2014. Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion. Nature. 508(7497):526-530. Comment in: Guillen, N. 2014. Infection biology: Nibbled to death. Nature. 508(7497):462-463. Comment in: Deresinski, S. 2014. Tissue destruction in amebiasis: chew on it. Clinical Infectious Diseases. 59(2):iii-iv.
Naylor, C, Burgess, S, Madan, R, Buonomo, E, Razzaq, K, Ralston, K, and Petri, WA, Jr. 2014. Leptin receptor mutation results in defective neutrophil recruitment to the colon during Entamoeba histolytica infection. mBio. 5(6):e02046-14.
Kisalu, NK, Langousis, G, Bentolila, LA, Ralston, KS, Weiss, S and Hill, KL. 2014. Mouse infection and pathogenesis by Trypanosoma brucei motility mutants. Cellular Microbiology. 16(6):912-24.
2013
Korpe, PS, Liu, Y, Siddique, A, Kabir, M, Ralston, KS, Ma, JZ, Haque, R and Petri, WA, Jr. 2013. A Prospective Cohort Study of Parasite-specific Breast Milk Antibodies and Protection from Enteric Protozoal Infection in Bangladeshi Infants. Clinical Infectious Diseases. 56(7):988-992.
Kato, K, Takegawa, Y, Ralston, KS, Gilchrist, CA, Hamano, S, Petri, WA, Jr. and Shinohara, Y. 2013. Sialic acid-dependent attachment of mucins from three mouse strains to Entamoeba histolytica. Biochemical and Biophysical Research Communication. 436(2):252-258.
2012
Royer, TL, Gilchrist, C, Kabir, M, Ralston, KS, Haque, R, Clark, CG and Petri, WA, Jr. 2012. Entamoeba bangladeshi n. sp.: A novel Entamoeba species identified in children in Bangladesh. Emerging Infectious Diseases. 18(9): 1543-1545.
Hughes, LC, Ralston, KS, Hill, KL and Zhou, ZH. 2012. Three-dimensional structure of the trypanosome flagellum suggests that the paraflagellar rod functions as a biomechanical spring. PLoS One. 7(1):e25700.
2011
Ralston, KS, Kisalu, N and Hill KL. 2011. Structure-function analysis of dynein light chain 1 identifies viable motility mutants in bloodstream-form Trypanosoma brucei. Eukaryotic Cell. 10(7):884-894. Journal Cover.
Ralston, KS and Petri, WA, Jr. 2011. Tissue destruction and invasion by Entamoeba histolytica. Trends in Parasitology. 27(6): 254-263. Journal Cover.
Ralston, KS and Petri, WA, Jr. 2011. The ways of a killer: how does Entamoeba histolytica elicit host cell death? Essays in Biochemistry. 51:193-210.
2009
Ralston KS, Kabututu ZP, Melehani JH, Oberholzer M and Hill KL. 2009. The Trypanosoma brucei flagellum: moving parasites in new directions. Annual Review of Microbiology. 63:335-362.
Oberholzer, M, Lopez, MA, Ralston, KS and Hill, KL. 2009. Approaches for functional analysis of flagellar proteins in African trypanosomes. Methods in Cell Biology. In: King, SM and Pazour, GJ editors; Cilia: Model Organisms and Intraflagellar Transport. p. 21-57. Academic Press. ISBN: 978-0-12-381377-0.
2008
Ralston, KS and Hill, KL. 2008. The flagellum of Trypanosoma brucei: new tricks from an old dog. International Journal of Parasitology. 38(8-9):869-884.
2007
Baron, DM, Ralston, KS, Kabututu, ZP and Hill, KL. 2007. Functional genomics in Trypanosoma brucei identifies evolutionarily-conserved components of motile flagella. Journal of Cell Science. 120(Pt 3):478-491.
2006
Ralston, KS and Hill, KL. 2006. Trypanin, a component of the flagellar dynein regulatory complex, is essential in bloodstream form African trypanosomes. PLoS Pathogens. 2(9):873-882.
Ralston, KS, Lerner, AG, Diener, DR and Hill, KL. 2006. Flagellar motility contributes to cytokinesis in Trypanosoma brucei and is modulated by an evolutionarily-conserved dynein regulatory system. Eukaryotic Cell. 5(4):696-711.
2005
Medina, V, Sudarshana, MR, Tian, T, Ralston, KS, Yeh, HH and Falk, BW. 2005. The Lettuce infectious yellows virus (LIYV)-encoded P26 is associated with plasmalemma deposits within LIYV-infected cells. Virology. 333(2):367-373.
2003
Hui, EKW, Ralston, K, Judd, AK and Nayak, DP. 2003. Conserved cysteine and histidine residues in the putative zinc finger motif of the influenza A virus M1 protein are not critical for influenza virus replication. Journal of General Virology. 84:3105-3113.
Ralston Lab 